Bob Martin Clear 3 in 1 Flavoured Wormer XL 525/504/175 mg Tablets for Large Dogs

Composition

Excipients

For the full list of excipients, see section 6.1

6.1 List of excipients

Artificial beef flavour Irradiated

Maize starch

Lactose monohydrate

Microcrystalline cellulose

Povidone K25

Magnesium stearate

Sodium laurilsulfate

Silica colloidal anhydrous

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Pharmaceutical form

Tablet.

Pale brown to brown oval shaped tablet scored on both sides.

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Pharmacological properties

The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances:

1) Febantel, a pro-benzimidazole, chemical name.

2) Pyrantel embonate (pamoate), a tetrahydropyrimidine derivative, and

3) Praziquantel, a partially hydrogenated pyrazino-isoquinoline derivative.

ATC VetCode: QP52AA51

5.1 Pharmacodynamic Properties

The product contains anthelmintics active against roundworms and tapeworms. The product contains three active substances: febantel, pyrantel embonate (pamoate) and praziquantel, a partially hydrogenated pyrazino-isoquinoline derivative used widely as an anthelmintic for both human and veterinary use.

Praziquantel is very rapidly absorbed and distributed throughout the parasite. Both in vivo and in vitro studies have shown that praziquantel causes severe damage to the parasite integument, resulting in contraction and paralysis. There is an almost instantaneous tetanic contraction of the parasite musculature and a rapid vacuolisation of the syncytial tegument. This rapid contraction has been explained by changes in divalent cation fluxes, especially calcium.

Pyrantel acts as a cholinergic agonist. Its mode of action is to stimulate nicotinic cholinergic receptors of the parasite, induce spastic paralysis and thereby allow removal from the gastro-intestinal (GI) system by peristalsis.

Within the mammalian system febantel undergoes ring closure forming fenbendazole and oxfendazole. It is these chemical entities which exert the anthelmintic effect by inhibition of tubulin polymerisation. Formation of microtubules is thereby prevented, resulting in disruption to structures vital to the normal functioning of the helminth. Glucose uptake, in particular, is affected, leading to a depletion in cell ATP. The parasite dies upon exhaustion of its energy reserves, which occurs 2-3 days later.

In this fixed combination pyrantel and febantel act against all relevant nematodes (ascarids, hookworms, and whipworms) in dogs. In particular the activity spectrum covers Toxocara canis, Toxascaris leonina, Uncinaria stenocephala, Ancylostoma caninum and Trichuris vulpis.

This combination shows synergistic activity in the case of hookworms and febantel is effective against T. vulpis.

The spectrum of activity of praziquantel covers all important cestode species in dogs, in particular Taenia spp; Dipylidium caninum; Echinococcus granulosus and Echinococcus multilocularis. Praziquantel acts against all adult and immature forms of these parasites.There is no known resistance to the active ingredients or the combination contained in Bob Martin Clear 3 in 1 Flavoured Wormer XL 525/504/175 mg Tablets for Large Dogs.

5.2 Pharmacokinetic Properties

Perorally administered praziquantel is absorbed almost completely from the intestinal tract. After absorption, the drug is distributed to all organs. Praziquantel is metabolized into inactive forms in the liver and secreted in bile. It is excreted within 24 hours to more than 95% of the administered dosage. Only traces of non-metabolised praziquantel are excreted.

Following administration of the product to dogs, peak plasma concentrations of praziquantel were achieved by approximately 2.5 hours.

The pamoate salt of pyrantel has low aqueous solubility, an attribute that reduces absorption from the gut and allows the drug to reach and be effective against parasites in the large intestine. Following absorption, pyrantel pamoate is quickly and almost completely metabolized into inactive metabolites that are excreted rapidly in the urine.

Febantel is absorbed relatively rapidly and metabolized to a number of metabolites including fenbendazole and oxfendazole, which have anthelmintic activity.

Following administration of the product to dogs, peak plasma concentrations of fenbendazole and oxfendazole were achieved by approximately 2-3 hours.

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Target species

Dogs.

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Indications

For the control of the following roundworms and tapeworms in adult dogs:

Ascarids: Toxocara canis, Toxascaris leonina (adult and late immature forms).

Hookworms: Uncinaria stenocephala, Ancylostoma caninum (adults)

Whipworms: Trichuris vulpis (adults)

Tapeworms: Echinococcus spp. Taenia spp. and Dipylidium caninum (adult and immature forms).

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Dosage

Dosage

The recommended dose rates are: 15 mg/kg bodyweight febantel, 14.4 mg/kg pyrantel and 5 mg/kg praziquantel. This is equivalent to 1 tablet per 35 kg bodyweight. It is important to follow the treatment recommendations as presented here. Do not deviate from the recommendations without the advice of your veterinary surgeon.

Administration and Duration of Treatment

Oral administration: the tablet(s) can be given directly to the dog or disguised in food. No starvation is needed before or after treatment.

For routine treatment a single dose is recommended.

For the control of Toxocara, nursing bitches should be dosed 2 weeks after giving birth and every 2 weeks until weaning.

For routine control adult dogs should be treated every 3 months. In case of suspected heavy roundworm infestation, please contact your veterinary surgeon for diagnosis and treatment recommendation

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Contraindications

Do not use simultaneously with piperazine compounds as piperazine may block the action of pyrantel embonate contained in Bob Martin Clear 3 in 1 Flavoured Wormer XL 525/504/175 mg Tablets for Large Dogs. Other worming products may contain piperazine.

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Adverse reactions

In very rare cases slight and transient digestive tract disorders such as vomiting and/or diarrhoea may occur. In individual cases these signs can be accompanied by nonspecific signs such as lethargy, anorexia or hyperactivity.

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Warnings

i) Special precautions for use in animals

Do not exceed the stated dose when treating pregnant bitches.

ii) Special precautions to be taken by the person administering the medicinal product to animals

In case of accidental ingestion, seek medical advice and show the package leaflet to the physician.

In the interests of good hygiene, persons administering the tablet directly to a dog or by adding it to the dog’s food, should wash their hands afterwards.

iii) Other precautions

Echinococcosis represents a hazard for humans. As Echinococcosis is a notifiable disease to the World Organisation for Animal Health (OIE), specific guidelines on the treatment and follow-up, and on the safeguard of persons, need to be obtained from the relevant competent authority.

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Use during pregnancy, lactation or lay

Consult a veterinary surgeon before treating pregnant animals. Bob Martin Clear 3 in 1 Flavoured Wormer XL 525/504/175 mg Tablets for Large Dogs may be used during lactation (see Section 4.9 below).

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Interactions

Do not use simultaneously with piperazine.

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Overdose

Bob Martin Clear 3 in 1 Flavoured Wormer XL 525/504/175 mg Tablets for Large Dogs is well tolerated in dogs. In safety studies doses of 5 x or greater gave rise to occasional vomiting.

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Special warnings

Dogs may become infected with worms by eating insects (including fleas and lice), birds, small rodents, rabbits or raw offal from affected sheep, goats and cattle. Dogs will continue to be re-infected unless the route of infection is controlled e.g. treating a flea infestation or preventing a dog from scavenging or hunting.

Echinococcus multilocularis is a tapeworm of foxes, dogs and cats which is common in parts of Europe. It can also infect humans potentially causing severe liver disease which can be fatal. To prevent Echinococcus multilocularis establishing in the UK and Ireland it is a requirement that all dogs must be treated with a product containing praziquantel before entering the country.

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Withdrawal period

Not applicable.

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Incompatibilities

None known.

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Immediate packaging

Container material:

- PVC-coated aluminium foil

- OPA/Alu/HDPE-aluminium foil strip

Container colour: White and silver

Container sizes: Cartons containing 2, 10, 20, and 50 tablets

Not all pack sizes may be marketed.

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Storage

Do not store above 25ºC.

Protect from light.

Any part-used tablets should be discarded.

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Shelf life

Shelf-life of the veterinary medicinal product as packaged for sale: 3 years.

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Disposal of unused product

Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal product should be disposed of in accordance with local requirements.

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Additional information

Vm 08007/5053

9 DATE OF FIRST AUTHORISATION

20 August 2002

10 DATE OF LAST REVISION OF THE TEXT

December 2025

Gavin Hall Approved: 09 December 2025

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Registration holder

Vetoquinol UK Limited

Steadings Barn

Pury Hill Business Park

Nr. Alderton

Towcester

Northamptonshire

NN12 7LS

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