Proactive 1.52 mg/ml Teat Dip/Spray Solution

Composition

One mL contains :

Active substance:

Iodine 1.52 mg

Excipients:

A red-brown liquid.

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Pharmacological properties

4.1 ATCvet code:

QD08AG03

4.2 Pharmacodynamics

The veterinary medicinal product is an antiseptic. The active form of this product is the free (molecular) iodine.

The mechanism of kill appears to be due to an oxidative reductive reaction, involving various cell wall constituents, which are irreversibly transformed. It appears sulfhydryl linkages, in bacteria cell wall components, are specifically targeted by the iodine. The veterinary medicinal product has been tested according to European Standards EN 1040 and EN 1656 against:

Pseudomonas aeruginosa

Staphylococcus aureus

Enterococcus hirae

Proteus vulgaris

4.3 Pharmacokinetics

Literature suggests that absorption of iodine through the skin is well below levels which would lead to pharmacokinetic activity in the body.

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Target species

Cattle (dairy cows).

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Indications

Teat disinfection as part of a strategy to reduce the incidence of mastitis in lactating cattle (mastitis prophylaxis).

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Dosage

Teat use.

Amounts to be administered: 5 ml per cow per application.

The veterinary medicinal product is meant to be used as a post-milking teat dip or spray up to two times per day. The duration of treatment is not limited.

Dip each teat of the cow immediately after milking in a dip cup containing undiluted veterinary medicinal product. Alternatively, spray the entire teats after each milking. Spraying must be done from below the teat. Ensure that the teat is covered to three quarters length and replenish the dip cup or spray container as necessary. The dip cup or spray container should be emptied after each milking and washed before reuse.

Ensure udder and teats are clean and dry before each milking.

If the veterinary medicinal product has frozen, thaw in a warm room and shake well before use.

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Contraindications

Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

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Adverse reactions

None known.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the label for respective contact details.

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Warnings

Special precautions for safe use in the target species:

For external use only. Use in injured teats may delay wound healing process. It is recommended that treatment be discontinued until teat lesions have resolved. Allow the veterinary medicinal product to dry before the cows are exposed to rain, cold or windy weather conditions

Special precautions to be taken by the person administering the veterinary medicinal product to animals:

People with known hypersensitivity to iodine or to any of the excipients should avoid contact with the veterinary medicinal product. If you develop symptoms following exposure, such as skin rash you should seek medical advice and show the combined package leaflet and label to the physician.

Avoid ingesting the veterinary medicinal product. In case of accidental ingestion seek medical advice immediately and show the combined package leaflet and label to the physician.

Do not eat, drink or smoke while using the veterinary medicinal product. When used as spray, avoid working in spray mist. This veterinary medicinal product might be mildly irritating to skin and eyes. Avoid contact with skin and eyes when administering the veterinary medicinal product. During application avoid contact with hands or wear protective gloves. If the veterinary medicinal product comes into contact with the eyes, rinse immediately with plenty of water.

Wash hands after use.

Special precautions for the protection of the environment:

Not applicable.

3.11 Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance

Not applicable.

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Use during pregnancy, lactation or lay

Pregnancy and lactation:

Can be used during pregnancy and lactation.

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Interactions

The veterinary medicinal product must not be used concurrently with other teat disinfectants or care products.

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Overdose

Not applicable, veterinary medicinal product is for topical application, significant absorption does not occur.

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Special warnings

The presence of milk or dirt neutralizes iodine, reducing its activity and effectiveness. Ensure that the udder and teats are clean and dry before the next milking.

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Withdrawal period

Meat and offal: Zero days.

Milk: Zero hours.

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Incompatibilities

In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products or alkalis or reducing substances.

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Immediate packaging

Opaque high-density polyethylene barrel of 5, 10, 20, 60 or 200 litre, with high-density polyethylene screw caps. Not all pack sizes may be marketed.

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Storage

Do not store above 25 °C.

Store upright in the tightly closed original container.

Protect from frost.

Protect from light.

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Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 30 months. Shelf life after first opening the immediate packaging: 1 year.

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Disposal of unused product

Use take-back schemes for the disposal of any unused veterinary medicinal product or waste materials derived thereof in accordance with local requirements and with any national collection systems applicable to the veterinary medicinal product concerned.

Medicines should not be disposed of via wastewater or household waste.

The veterinary medicinal product should not enter water courses as iodine may be dangerous for fish and other aquatic organisms.

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Additional information

Vm 17140/3001

Vm 17140/5001

8 DATE OF FIRST AUTHORISATION

05 July 2000

9 DATE OF THE LAST REVISION OF THE SUMMARY OF THE PRODUCT CHARACTERISTICS

July 2025

10 CLASSIFICATION OF VETERINARY MEDICINAL PRODUCT

Veterinary medicinal product not subject to prescription.

Find more product information by searching for the ‘Product Information Database’ on www.gov.uk.

Approved: 11 August 2025

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Registration holder

DeLaval NV

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