Canergy 100 mg Tablets for Dogs

Composition

Each tablet contains:

Active substance:

Propentofylline 100 mg

Excipients:

Qualitative composition of excipients and other constituents

Lactose monohydrate

Maize starch

Crospovidone (type A)

Purified talc

Colloidal anhydrous silica

Calcium behenate

Yeast, deactivated

Artificial beef flavour

Light brown with brown spots, round and convex flavoured tablet with a cross-shaped break line on one side.

The tablets can be divided into 2 or 4 equal parts.

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Pharmacological properties

4.1 ATCvet code: QC04AD90

4.2 Pharmacodynamics

Propentofylline has been shown to increase blood flow, particularly of the heart and skeletal muscle. It also increases the blood flow of the brain and therefore its oxygen supply, without increasing the brain's glucose demand. It has a modest positive chronotropic effect and a marked positive inotropic effect. In addition, it has been shown to have an anti-arrhythmic effect in dogs with myocardial ischemia and a bronchodilator action equivalent to that of aminofylline.

Propentofylline inhibits platelet aggregation and improves the flow properties of erythrocytes.

It has a direct effect on the heart and reduces peripheral vascular resistance thereby lowering cardiac load.

Propentofylline may increase willingness to exercise and exercise tolerance, particularly in older dogs.

4.3 Pharmacokinetics

After oral administration propentofylline is rapidly and completely absorbed and quickly distributed in the tissues. Maximum plasma levels are reached by 15 minutes following oral dosing in dogs.

The half-life is about 30 minutes and the bioavailability for the parent compound is approximately 30 %. There are a number of effective metabolites and the biotransformation takes place mainly in the liver. 80 – 90 % of propentofylline is excreted in the form of metabolites via the kidneys. The rest is eliminated in faeces. There is no bioaccumulation.

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Target species

Dogs.

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Indications

For the improvement of peripheral and cerebral vascular blood circulation. For improvement in dullness, lethargy and overall demeanour in dogs.

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Dosage

Oral use.

To ensure a correct dosage, body weight should be determined as accurately as possible before treatment. The basic dosage is 6 - 10 mg propentofylline/kg bodyweight daily, divided into two doses as follows:

100 mg Tablets

= ¼ Tablet = ½ Tablet = ¾ Tablet = 1 Tablet

The tablets can be administered directly in the mouth, onto the back of the dog's tongue or can be mixed in a small ball of food and should be administered at least 30 minutes before feeding.

Tablets can be divided into 2 or 4 equal parts to ensure accurate dosing. Place the tablet on a flat surface, with its scored side facing up and the convex (rounded) side facing the surface.

Halves: press down with your thumbs on both sides of the tablet.

Quarters: press down with your thumb in the middle of the tablet.

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Contraindications

Do not use in dogs weighing less than 5 kg.

Do not use in cases of hypersensitivity to the active substance or to any of the excipients.

See also section 3.7.

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Adverse reactions

Dogs:

Rare (1 to 10 animals / 10,000 animals treated): Allergic skin reaction a, Cardiac disorder a, Vomiting a

a In these cases the treatment should be stopped.

Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.

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Warnings

Special precautions for safe use in the target species:

Specific diseases (e.g. kidney disease) should be treated accordingly.

Consideration should be given to rationalising the medication of dogs already receiving treatment for congestive heart failure or bronchial disease.

In the case of renal failure, the dose should be reduced.

The tablets are flavoured. In order to avoid any accidental ingestion, store tablets out of reach of the animals.

Special precautions to be taken by the person administering the veterinary medicinal product to animals:

Care should be taken to avoid accidental ingestion.

In case of accidental ingestion, seek medical advice immediately and show the package leaflet or the label to the physician. Wash hands after use.

Any unused tablet portion should be returned to the open blister and inserted back into the carton to be used for the next administration.

Special precautions for the protection of the environment:

Not applicable.

3.11 Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance

Not applicable.

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Use during pregnancy, lactation or lay

The safety of the veterinary medicinal product has not been established during pregnancy and/or lactation.

Pregnancy and lactation:

Use in pregnant or lactating bitches or breeding animals is not recommended.

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Interactions

None known.

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Overdose

Excitation tachycardia, hypotension, reddening of mucous membranes and vomiting. The withdrawal of the treatment leads to a spontaneous remission of these signs.

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Special warnings

None.

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Withdrawal period

Not applicable.

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Incompatibilities

Not applicable.

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Immediate packaging

Aluminium - PA/ALU/PVC blister.

Cardboard box of 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 25 or 50 blisters of 10 tablets.

Not all pack sizes may be marketed.

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Storage

This veterinary medicinal product does not require any special temperature storage conditions.

Any unused tablet portion should be returned to the open blister and inserted back into the carton to be used for the next administration.

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Shelf life

Shelf life of the veterinary medicinal product as packaged for sale: 3 years. Shelf life after first opening the immediate packaging: 4 days.

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Disposal of unused product

Medicines should not be disposed of via wastewater.

Use take-back schemes for the disposal of any unused veterinary medicinal product or waste materials derived thereof in accordance with local requirements and with any national collection systems applicable to the veterinary medicinal product concerned.

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Additional information

Vm 41821/4019

8 DATE OF FIRST AUTHORISATION

21 May 2015.

9 DATE OF THE LAST REVISION OF THE SUMMARY OF THE PRODUCT CHARACTERISTICS

April 2026

10 CLASSIFICATION OF VETERINARY MEDICINAL PRODUCT

Veterinary medicinal product subject to prescription.

Find more product information by searching for the ‘Product Information Database’ on www.gov.uk.

Approved: 01 May 2026

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Registration holder

Le Vet Beheer B.V.

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