Vomend 5 mg/ml Solution for Injection for Dogs and Cats
Metoclopramide Hydrochloride
Last verified
Veterinary medicinal product: solution for injection. Distribution category: POM-V (Veterinary Medicines Regulations 2013, Schedule 3). Active substance: Metoclopramide Hydrochloride.1
- Dispensing
- Prescription only1
POM-V: Prescription Only Medicine - Veterinarian. Supplied only on a prescription written by a veterinary surgeon who has assessed the animal.12
Supplied only on a veterinarian's prescription. As stated in the registration decision.
- Active substance
- Metoclopramide Hydrochloride
- ATCvet code
- QA03FA013
- Manufacturer
- Marketing authorisation holder: Eurovet Animal Health B.V.
Withdrawal period
No withdrawal period is set for this drug: it is not intended for food-producing animals.3
Summary of product characteristics
Composition
Each ml contains:
Active substance:
Metoclopramide (as hydrochloride monohydrate) 4.457 mg
equivalent to metoclopramide hydrochloride 5 mg
Excipients:
| Qualitative composition of excipients and other constituents | Quantitative composition if that information is essential for proper administration of the veterinary medicinal product |
|---|---|
| Benzyl alcohol (E1519) | 18 mg |
| Sodium chloride | |
| Sodium hydroxide (E524-for pH adjustment) | |
| Hydrochloric acid (E507-for pH adjustment) | |
| Water for injections |
Clear colourless aqueous solution.
Pharmacological properties
4.1 ATCvet code: QA03FA01
4.2 Pharmacodynamics
Metoclopramide is an original orthopramide molecule.
The anti-emetic action of metoclopramide is mainly due to its antagonist activity at D2 receptors in the central nervous system, preventing nausea and vomiting triggered by most stimuli.
The prokinetic effect on the gastro-duodenal transit (increase in intensity and rhythm of stomach contractions and opening of the pylorus) is mediated by muscarinic activity, D2 receptor antagonist activity and 5-HT4 receptor agonist activity at the gastrointestinal level.
4.3 Pharmacokinetics
Metoclopramide is rapidly and completely absorbed after parenteral administration. After subcutaneous administration to dogs and cats, maximum concentrations are obtained after 15-30 minutes.
Metoclopramide is rapidly distributed into most tissues and fluids, crosses the blood-brain barrier and enters the central nervous system.
Metoclopramide is metabolised by the liver.
The elimination of metoclopramide is rapid, 65% of the dose being eliminated within 24 hours in the dog, primarily by the urinary route.
Target species
Dogs, cats.
Indications
Symptomatic treatment of vomiting and reduced gastrointestinal motility associated with gastritis, pyloric spasm, chronic nephritis and digestive intolerance to some drugs.
Dosage
Intramuscular or subcutaneous use.
0.5 mg metoclopramide hydrochloride per kg body weight, if necessary repeated every 6-8 hours.
Contraindications
Do not use in cases of gastrointestinal perforation or obstruction.
Do not use in cases of hypersensitivity to the active substance or to any of the excipients.
Adverse reactions
Dogs, cats:
| Frequency | Adverse events |
|---|---|
| Very rare (<1 animal / 10,000 animals treated, including isolated reports): | Extrapyramidal effects a (agitation, ataxia, abnormal positions and/or movements, prostration, tremors, aggression, vocalisation) |
| Allergic reaction |
a The observed effects are transient and disappear when treatment is stopped.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to either the marketing authorisation holder or its local representative or the national competent authority via the national reporting system. See the package leaflet for respective contact details.
Warnings
Special precautions for safe use in the target species:
The dosage must be adapted in animals with renal or hepatic insufficiency (due to an increase in the risk of side effects). Avoid administration to animals with epilepsy. The dosage should be carefully observed, especially in cats and small breed dogs. Following prolonged vomiting, consideration should be given to fluid and electrolyte replacement therapy.
Special precautions to be taken by the person administering the veterinary medicinal product to animals
Wash hands after administration to the animal.
In case of accidental self-injection, seek medical advice immediately and show the package leaflet or the label to the physician.
In case of accidental exposure by spillage onto the skin or eyes, wash immediately with abundant water. If an adverse effect occurs, seek medical advice immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.
3.11 Special restrictions for use and special conditions for use, including restrictions on the use of antimicrobial and antiparasitic veterinary medicinal products in order to limit the risk of development of resistance
Not applicable.
Use during pregnancy, lactation or lay
Pregnancy and lactation:
Laboratory studies in laboratory animals have not produced any evidence of teratogenic or foetotoxic effects. However, studies in laboratory animals are limited and the safety of the active substance has not been evaluated in the target species. Use only according to the benefit-risk assessment by the responsible veterinarian.
Interactions
In cases of gastritis, avoid the co-administration of anticholinergic drugs (atropine) as they may counteract the effects of metoclopramide on gastrointestinal motility.
In cases of simultaneous diarrhoea, there is no contraindication to the use of anticholinergic drugs.
Concurrent use of metoclopramide with neuroleptics derived from phenothiazine (acepromazine) and butyrophenones increases the risk of extrapyramidal effects (see section 3.6).
Metoclopramide can potentiate the action of central nervous system depressants. If used concurrently, it is advised to use the lowest dosage of metoclopramide to avoid excessive sedation.
Overdose
Most of the clinical signs reported after an overdose are well known extrapyramidal side effects (see section 3.6).
In the absence of a specific antidote, it is recommended to offer a calm environment to the animal until the extrapyramidal side effects disappear.
Metoclopramide being rapidly metabolised and eliminated, side effects generally disappear quickly.
Special warnings
None.
Withdrawal period
Not applicable
Incompatibilities
In the absence of compatibility studies, this veterinary medicinal product must not be mixed with other veterinary medicinal products.
Immediate packaging
One colourless clear glass vial (type I) with a bromobutyl rubber stopper and aluminium cap in a cardboard box.
Pack sizes:
Cardboard box containing 1 vial of 5 ml, 10 ml, 20 ml, 25 ml, 30 ml and 50 ml.
Not all pack sizes may be marketed.
Storage
Store in the original package.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 2 years.
Shelf life after first opening the immediate packaging: 28 days.
Disposal of unused product
Medicines should not be disposed of via wastewater.
Use take-back schemes for the disposal of any unused veterinary medicinal product or waste materials derived thereof in accordance with local requirements and with any national collection systems applicable to the veterinary medicinal product concerned.
Additional information
UK(GB) Vm 16849/5013
UK(NI) Vm 16849/3013
8 DATE OF FIRST AUTHORISATION
20 December 2010
9 DATE OF THE LAST REVISION OF THE SUMMARY OF THE PRODUCT CHARACTERISTICS
December 2024
10 CLASSIFICATION OF VETERINARY MEDICINAL PRODUCT
Veterinary medicinal product subject to prescription.
Find more product information by searching for the ‘Product Information Database’ on www.gov.uk.
Approved: 24 July 2025
Registration holder
Eurovet Animal Health B.V.
Regulations
- Veterinary Medicines Regulations 2013 (SI 2013/2033), Schedule 32