Phosphorus Supplement 1.8% w/v Solution for Injection
Phosphorus
Last verified
Veterinary medicinal product: solution for injection. Distribution category: POM-V (Veterinary Medicines Regulations 2013, Schedule 3). Active substance: Phosphorus.1
In short: questions and answers
- Does Phosphorus Supplement 1.8% w/v Solution for Injection need a prescription?
- Prescription only. As stated in the registration decision.1
- Which animals is Phosphorus Supplement 1.8% w/v Solution for Injection for?
- Cattle.1
- What is the active substance in Phosphorus Supplement 1.8% w/v Solution for Injection?
- Phosphorus. ATCvet code: QA12CX.13
- What is the withdrawal period of Phosphorus Supplement 1.8% w/v Solution for Injection according to the leaflet?
- Cattle, meat: 0 days; Cattle, milk: 0 days.3
- Dispensing
- Prescription only1
POM-V: Prescription Only Medicine - Veterinarian. Supplied only on a prescription written by a veterinary surgeon who has assessed the animal.12
Supplied only on a veterinarian's prescription. As stated in the registration decision.
- Animal species
- Cattle1
- Active substance
- Phosphorus
- ATCvet code
- QA12CX3
- Manufacturer
- Marketing authorisation holder: Alfasan Nederland B.V.
Withdrawal period
Summary of product characteristics
Composition
Active substance
| Qualitative composition | Quantitative composition |
|---|---|
| Calcium hypophosphite | 4.84 % w/v |
| (equivalent to Phosphorus 1.8 % w/v) |
Excipients
For a full list of excipients, see section 6.1.
List of excipients
Water for injections
Pharmaceutical form
Solution for injection.
A clear, colourless, sterile, aqueous solution.
Pharmacological properties
Pharmacotherapeutic group:
Mineral supplements, Other mineral supplements, Other mineral products.
ATC Vet Code:
QA12CX
Pharmacodynamic properties
Hypophosphataemia is a nutritional disorder affecting cattle. It is characterised by a decrease in the plasma phosphorus concentration to below the normal range. The condition is often associated with deficiencies in calcium and magnesium such as post-parturient paresis, lactation tetany and grass tetany.
Phosphorus, in the form of phosphates, is the principle anion of intracellular fluid. Phosphorus and calcium are intricately involved in bone growth and calcification. Phosphate is mainly used in metabolism of carbohydrates and lipids, the storage and transfer of energy in cells occurring in nucleic acids, the formation of the body buffering system which influences acid-base balance, and in the renal excretion of hydrogen ions in the urine. Where there is a soil phosphate deficiency, animals require supplementation to prevent the appearance of chronic deficiency (characterised by anorexia and pica, impaired weight gain, infertility and lameness).
Commercial preparations, usually containing calcium and phosphorus as the hypophosphite, are used. Up to 100 mmol per day may be given by slow intravenous injection in cases of severe hypophosphataemia. Plasma electrolyte concentrations, especially phosphate and calcium should be monitored. In excess, the more soluble phosphates have a laxative effect which is counter-productive.
Injections can be given intravenously, using normal aseptic techniques. Excessive administration of phosphate may cause hyperphosphataemia.
Pharmacokinetic properties
The metabolism of cyanocobalamin is complex and is associated closely with that of folic acid and of ascorbic acid. It is important for maintenance of normal haemopoiesis, protection of the liver, maintenance of muscle tissue, healthy skin, brain and pancreatic metabolism.
Target species
Cattle.
Indications
For the treatment of acute hypophosphataemia in cattle. Also as an aid in raising blood calcium levels where a deficiency may be expected.
Dosage
Cattle: up to 400 ml by intravenous injection (approximately 1 ml/kg/day).
Contraindications
Do not use in hyperphosphataemic animals.
Adverse reactions
None known.
Warnings
i. Special precautions for use in animals
None known.
ii. Special precautions for the person administering the veterinary medicinal product to animals
If contact with the skin occurs, the area should be washed with soap and water. If irritation occurs, seek medical advice.
If contact with eyes occurs, wash eyes with plenty of clean water. If irritation occurs, seek medical advice.
Following oral ingestion, the mouth should be washed out and plenty of water consumed. Seek medical advice if irritation occurs.
If accidental self-injection occurs or if signs of adverse effects are seen, seek medical attention immediately, showing the product label to a doctor. Wash hands after use.
Use during pregnancy, lactation or lay
Not contraindicated.
Interactions
None known.
Overdose
Do not exceed stated dose.
Special warnings
Preferably warm the solution to body temperature before use.
Withdrawal period
Meat: zero days.
Milk: zero hours.
Incompatibilities
None known.
Immediate packaging
400 ml type II amber glass bottle, fitted with a grey rubber stopper and push off polypropylene cap.
Storage
Do not store above 25°C.
Protect from light.
This product does not contain an antimicrobial preservative. Any remaining solution in the bottle following withdrawal of the required dose should be discarded.
Shelf life
Shelf life of the veterinary medicinal product as packaged for sale: 3 years.
Disposal of unused product
Any unused veterinary medicinal product or waste materials derived from such veterinary medicinal products should be disposed of in accordance with local requirements.
Additional information
Vm 36408/4010
DATE OF FIRST AUTHORISATION
06 July 1995
DATE OF REVISION OF THE TEXT
August 2021
Registration holder
Alfasan Nederland B.V.
Kuipersweg 9
3449 JA Woerden
The Netherlands
Regulations
- Veterinary Medicines Regulations 2013 (SI 2013/2033), Schedule 32